Commit 7fb3e6e3 authored by matecellab's avatar matecellab
Browse files

added ref for Bosboom

parent edf07b53
......@@ -14,6 +14,15 @@ Sarah~J. Armstrong, Richard~A. Read and Roger Price.
\newblock \pmid{7719953}.
\newblock \doi{10.1016/S1063-4584(05)80035-4}.
\bibitem{Bosboom2003}
E.M.H. Bosboom, C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens and K.~Nicolay.
\newblock {Q}uantifying pressure sore-related muscle damage using
high-resolution {MRI}.
\newblock \emph{Journal of Applied Physiology}, \textbf{95}(6):2235--2240,
December 2003.
\newblock \pmid{12819217}.
\newblock \doi{10.1152/japplphysiol.01023.2001}.
\bibitem{Ceelen2008}
K.K. Ceelen, A.~Stekelenburg, S.~Loerakker, G.J. Strijkers, D.L. Bader,
K.~Nicolay, F.P.T. Baaijens and C.W.J. Oomens.
......
......@@ -3,7 +3,7 @@
The use of an ovine model circumvents the ethical and financial problems associated with the use of bipedal animal models. \qauthor{Armstrong, Read \& Price \cite{Armstrong1995} }
\end{savequote}
\chapter{Introduction}
Pressure ulcers are localised injuries to the skin and/or underlying tissue due to mechanical loading. Deep Tissue Injury is a severe type of pressure ulcer originating subcutaneously. To better understand the aetiology of Deep Tissue Injury, \href{https://www.tue.nl/stbe}{our group} studies physiological changes due to mechanical loading in a rat model \cite{Loerakker2010,Loerakker2011,Loerakker2011a,Oomens2010,Nierop2010,Ceelen2008, Stekelenburg2006, Stekelenburg2006a, Stekelenburg2007}. In this rat model, the animal's tibialis anterior muscle is deformed with an indenter inside a magnetic resonance (MR) imaging scanner. MR imaging allows for assessment of physiological changes, e.g. (re)perfusion and tissue damage, due to the deformation of the muscle. Animal specific finite element (FE) models are used to assess the relationship between the mechanical internal tissue state and tissue damage in the rat model.
Pressure ulcers are localised injuries to the skin and/or underlying tissue due to mechanical loading. Deep Tissue Injury is a severe type of pressure ulcer originating subcutaneously. To better understand the aetiology of Deep Tissue Injury, \href{https://www.tue.nl/stbe}{our group} studies physiological changes due to mechanical loading in a rat model \cite{Bosboom2003,Loerakker2010,Loerakker2011,Loerakker2011a,Oomens2010,Nierop2010,Ceelen2008, Stekelenburg2006, Stekelenburg2006a, Stekelenburg2007}. In this rat model, the animal's tibialis anterior muscle is deformed with an indenter inside a magnetic resonance (MR) imaging scanner. MR imaging allows for assessment of physiological changes, e.g. (re)perfusion and tissue damage, due to the deformation of the muscle. Animal specific finite element (FE) models are used to assess the relationship between the mechanical internal tissue state and tissue damage in the rat model.
Until recently, (animal specific) FE analysis of the experiments was restricted to cross sectional (2D) FE models. In the current project \textsl{Non-invasive monitoring of deep tissue injury} \cite{Traa2015} the aim is to extend a previously developed cross sectional (2D) FE models \cite{Loerakker2010} to a FE model of the complete leg (i.e.\ 3D) \cite{Traa2014}. The first objective of these animal specific full leg 3D models is to assess the shortcomings of cross sectional 2D modelling (or: to assess what extra information can be obtained by switching to full leg 3D modelling).\\
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